Skin
Medicines for Blisters
Small pockets of fluid under the skin, usually from friction, burns or other damage — mostly harmless and healing on their own, where leaving them intact protects against infection.
Education and reference only. This explains which medicines are used and why, in plain language — it deliberately contains no doses and is not a substitute for advice from your doctor or pharmacist. Always discuss your own treatment with a qualified clinician, and check the BNF and the product labelling for prescribing detail.
Quick answer
What is Blisters?
Blisters are small pockets of fluid that form in the upper layers of the skin, usually as a way of protecting the damaged skin underneath and helping it heal. They are very common and usually harmless.
- How it is treated: Most blisters, particularly friction blisters, heal on their own within a few days to a week or so, and the key to caring for them is to protect the blister and, wherever possible, leave it intact.
- Self-care: Leaving a blister intact (not bursting it) to protect the skin underneath, covering it with a plaster or dressing, and avoiding the cause while it heals help most blisters heal within days.
- When to seek help: See a pharmacist or GP if a blister looks infected (increasingly painful, red, swollen, warm, oozing pus, or with feeling unwell), is very large or painful, is caused by a burn or scald, keeps recurring, appears without a clear cause, or if there is widespread blistering — as these may need treatment or indicate an underlying condition.
What it is
Blisters are small pockets of fluid that form in the upper layers of the skin, usually as a way of protecting the damaged skin underneath and helping it heal. They are very common and usually harmless. The most common cause is friction — for example from ill-fitting or new shoes rubbing the feet, or from using tools or equipment that rub the hands — but blisters can also be caused by burns and scalds, sunburn, contact with certain chemicals or substances, extreme cold, allergic reactions, and some skin conditions and infections (such as chickenpox, cold sores, shingles, or impetigo). A friction blister is typically a raised bubble of skin filled with clear fluid; blisters can sometimes be filled with blood (blood blisters) or, if infected, with pus. Most blisters, particularly friction blisters, heal by themselves within a few days to a week or so without any specific treatment, as the fluid is gradually reabsorbed and new skin forms underneath. The most important point in caring for a blister is, wherever possible, to leave it intact and not to burst it, because the blister’s "roof" of skin protects the raw skin underneath from infection while it heals. Covering the blister can protect it, and simple measures relieve discomfort. Most blisters need no medical attention. However, some situations need care or advice — for example blisters caused by burns, large or very painful blisters, blisters that look infected, blisters with no clear cause, or widespread or recurring blistering (which can be a sign of an underlying condition). Preventing friction blisters — for example by wearing well-fitting footwear and protecting the skin — is also worthwhile.
How it is treated
Most blisters, particularly friction blisters, heal on their own within a few days to a week or so, and the key to caring for them is to protect the blister and, wherever possible, leave it intact. Helpful measures include: not bursting or peeling a blister if possible, as the skin over it protects the raw skin underneath from infection while it heals; covering the blister with a plaster or dressing (a soft, cushioned or blister plaster can protect it and relieve pressure), particularly if it is in a place that gets rubbed; avoiding the activity or footwear that caused it while it heals; and keeping the area clean. If a blister bursts on its own, it is best to let the fluid drain, not to peel off the loose skin (leaving it as a natural cover), and to keep the area clean and covered. In some cases, a large or painful blister may be carefully drained by a health professional, but generally it is best not to deliberately burst blisters at home. Blisters caused by burns should be treated as burns (cooling the burn and seeking advice as appropriate) and not burst. It is worth seeking advice if a blister looks infected (increasingly painful, red, swollen, warm, or oozing pus, or with feeling unwell), is very large or painful, is caused by a burn or scald, keeps coming back, appears without a clear cause, or if there is widespread blistering — as these may need treatment or point to an underlying cause. Preventing friction blisters is worthwhile: wearing well-fitting, comfortable footwear and breaking in new shoes gradually, wearing socks that reduce rubbing, protecting areas prone to rubbing, and wearing gloves for tasks that rub the hands all help. The reassuring messages are that most blisters are harmless and heal on their own, that leaving them intact protects against infection, and that simple protection and prevention are usually all that is needed — while infected, large, burn-related, unexplained, or widespread blisters should be checked.
For this condition, these medicines
Medicine classes used for Blisters
Each links to a full, dose-free guide — what it is, how it works, who can and cannot use it, side effects, interactions and FAQs.
Beyond medication
Lifestyle and self-care
Leaving a blister intact (not bursting it) to protect the skin underneath, covering it with a plaster or dressing, and avoiding the cause while it heals help most blisters heal within days. Preventing friction blisters — well-fitting footwear, breaking in new shoes gradually, socks that reduce rubbing, and gloves for hand tasks — is worthwhile. Infected or unexplained blisters should be checked.
When to get help
When to see a doctor
See a pharmacist or GP if a blister looks infected (increasingly painful, red, swollen, warm, oozing pus, or with feeling unwell), is very large or painful, is caused by a burn or scald, keeps recurring, appears without a clear cause, or if there is widespread blistering — as these may need treatment or indicate an underlying condition. Most blisters, though, are harmless and heal on their own.
Not sure how urgent it is? It is always OK to call NHS 111 for advice, day or night.
Answers
Blisters: frequently asked questions
Should you pop a blister?
Generally no — it is best to leave a blister intact and not burst it, because the skin over the blister protects the raw skin underneath from infection while it heals. Cover it to protect it, and avoid the cause. If a blister bursts on its own, let it drain, leave the loose skin as a cover, and keep the area clean and covered.
How long do blisters take to heal?
Most blisters, especially friction blisters, heal by themselves within a few days to a week or so, as the fluid is reabsorbed and new skin forms underneath. Protecting the blister and leaving it intact help. See a pharmacist or GP if a blister looks infected, is very large or painful, is from a burn, keeps recurring, or appears without a clear cause.
Keep reading
Related articles
Sources
Where this is drawn from
- NHS — Blisters
- NHS — Burns and scalds
Related conditions
Browse by body system
Building a patient-information or formulary resource?
We create evidence-led, dose-free clinical references and decision aids for teams.