Musculoskeletal
Medicines for Dupuytren's contracture
A condition where the tissue under the skin of the palm thickens and tightens, gradually pulling one or more fingers into a bent position — treated when it limits hand function.
Education and reference only. This explains which medicines are used and why, in plain language — it deliberately contains no doses and is not a substitute for advice from your doctor or pharmacist. Always discuss your own treatment with a qualified clinician, and check the BNF and the product labelling for prescribing detail.
Quick answer
What is Dupuytren's contracture?
Dupuytren's contracture is a condition in which the layer of tissue under the skin of the palm gradually thickens and forms cords, which can slowly pull one or more fingers (often the ring and little fingers) towards the palm so they cannot fully straighten. It usually develops slowly over years, often starting as a firm nodule in the palm, and is usually painless.
- How it is treated: Treatment is guided by how much the condition affects hand function rather than its appearance alone.
- Self-care: There is no proven way to prevent progression, but keeping the hand active, and having it assessed when it starts to limit function (such as laying the hand flat), ensures timely treatment.
- When to seek help: See a GP if a finger is becoming bent and you cannot fully straighten it or lay your hand flat, or if it is affecting daily tasks, for referral to a hand specialist.
What it is
Dupuytren's contracture is a condition in which the layer of tissue under the skin of the palm gradually thickens and forms cords, which can slowly pull one or more fingers (often the ring and little fingers) towards the palm so they cannot fully straighten. It usually develops slowly over years, often starting as a firm nodule in the palm, and is usually painless. It is more common in older men, tends to run in families, and is linked to factors such as diabetes and alcohol. While it does not usually hurt, it can make it hard to lay the hand flat, put on gloves, or do everyday tasks.
How it is treated
Treatment is guided by how much the condition affects hand function rather than its appearance alone. Early, mild disease that does not limit the hand is usually just monitored. When a finger becomes bent enough to interfere with daily activities, treatments that release or divide the tightened cords can restore movement — these range from a needle technique or an enzyme injection to surgery, depending on the severity and individual factors. The condition can recur after treatment, and the best option is discussed with a hand specialist.
For this condition, these medicines
Medicine classes used for Dupuytren's contracture
Each links to a full, dose-free guide — what it is, how it works, who can and cannot use it, side effects, interactions and FAQs.
Beyond medication
Lifestyle and self-care
There is no proven way to prevent progression, but keeping the hand active, and having it assessed when it starts to limit function (such as laying the hand flat), ensures timely treatment. Managing diabetes and alcohol intake is generally advisable.
When to get help
When to see a doctor
See a GP if a finger is becoming bent and you cannot fully straighten it or lay your hand flat, or if it is affecting daily tasks, for referral to a hand specialist.
Not sure how urgent it is? It is always OK to call NHS 111 for advice, day or night.
Answers
Dupuytren's contracture: frequently asked questions
Is Dupuytren's contracture painful?
Usually not — it is typically painless, but the gradual bending of the fingers can make everyday tasks difficult, which is when treatment is considered.
How is Dupuytren's contracture treated?
When it limits hand function, treatments that release the tightened cords — a needle technique, an enzyme injection, or surgery — can restore movement. Mild cases are often just monitored.
Sources
Where this is drawn from
- NHS — Dupuytren's contracture
- British Society for Surgery of the Hand guidance
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