Skin
Medicines for Erysipelas
A bacterial skin infection affecting the upper skin layers, causing a well-defined, raised, red and painful area — treatable with antibiotics.
Education and reference only. This explains which medicines are used and why, in plain language — it deliberately contains no doses and is not a substitute for advice from your doctor or pharmacist. Always discuss your own treatment with a qualified clinician, and check the BNF and the product labelling for prescribing detail.
Quick answer
What is Erysipelas?
Erysipelas is a bacterial infection of the skin, closely related to cellulitis, that affects the upper layers of the skin and the surface lymphatic vessels. It is usually caused by streptococcus bacteria, which enter through a break in the skin (such as a cut, graze, insect bite, or a skin condition like athlete's foot or eczema).
- How it is treated: Erysipelas is treated with antibiotics, which are usually effective, and prompt treatment is important.
- Self-care: Resting and elevating an affected leg, simple pain relief, staying hydrated, and completing the antibiotic course all help.
- When to seek help: See a GP promptly about a spreading area of red, swollen, warm, painful skin with a raised, well-defined border, especially with fever or feeling unwell — erysipelas needs antibiotic treatment.
What it is
Erysipelas is a bacterial infection of the skin, closely related to cellulitis, that affects the upper layers of the skin and the surface lymphatic vessels. It is usually caused by streptococcus bacteria, which enter through a break in the skin (such as a cut, graze, insect bite, or a skin condition like athlete's foot or eczema). It causes an area of skin that becomes red or discoloured, swollen, warm, and painful or tender, and — a feature that helps distinguish it from ordinary cellulitis — the affected area is typically raised, firm, and has a clearly defined, sharp border between the affected and normal skin. It most commonly affects the legs and the face. It often comes on quite quickly and may be accompanied by feeling generally unwell, with fever, chills, and shivering. Erysipelas is more common in certain people, including those with skin breaks, leg swelling, or reduced immunity. It is a treatable infection, but, like cellulitis, it needs prompt treatment with antibiotics, because untreated it can spread and, occasionally, cause more serious problems.
How it is treated
Erysipelas is treated with antibiotics, which are usually effective, and prompt treatment is important. For many people, antibiotic tablets and supportive care are sufficient, and the infection improves over several days. Supportive measures help: resting and, if a leg is affected, elevating it to reduce swelling; simple pain relief; and staying hydrated. Marking the edge of the affected area can help track whether it is responding to treatment. More severe infection, involvement of the face, being very unwell, or not responding to tablets may require antibiotics given into a vein, sometimes in hospital. Importantly, treating any underlying cause or entry point for the bacteria — such as athlete's foot, a skin wound, eczema, or leg swelling — helps the infection settle and reduces the chance of it coming back, as erysipelas (like cellulitis) can recur, particularly in people with ongoing skin breaks or leg swelling; in those with recurrent episodes, preventive measures and sometimes long-term preventive antibiotics are considered. The reassuring message is that erysipelas is a treatable bacterial skin infection that usually responds well to antibiotics, and that treating the entry point and any underlying factors helps prevent it recurring.
For this condition, these medicines
Medicine classes used for Erysipelas
Each links to a full, dose-free guide — what it is, how it works, who can and cannot use it, side effects, interactions and FAQs.
Beyond medication
Lifestyle and self-care
Resting and elevating an affected leg, simple pain relief, staying hydrated, and completing the antibiotic course all help. Treating any entry point (such as athlete's foot, cuts, or eczema) and managing leg swelling help the infection settle and reduce the chance of it recurring.
When to get help
When to see a doctor
See a GP promptly about a spreading area of red, swollen, warm, painful skin with a raised, well-defined border, especially with fever or feeling unwell — erysipelas needs antibiotic treatment. Seek urgent care if you feel very unwell, the area spreads rapidly, or the face is affected.
Not sure how urgent it is? It is always OK to call NHS 111 for advice, day or night.
Answers
Erysipelas: frequently asked questions
What is the difference between erysipelas and cellulitis?
They are closely related bacterial skin infections. Erysipelas affects the upper layers of the skin and typically causes a raised area with a sharp, well-defined border, whereas cellulitis affects deeper layers with a less distinct edge. Both are treated with antibiotics.
How is erysipelas treated?
With antibiotics (tablets for many people, or into a vein for more severe cases), which are usually effective, plus supportive measures such as resting and elevating an affected leg. Treating the entry point (such as athlete's foot or a wound) helps it settle and prevents recurrence.
Sources
Where this is drawn from
- NHS — Cellulitis and erysipelas
- NICE NG141 — Cellulitis and erysipelas
Related conditions
Browse by body system
Building a patient-information or formulary resource?
We create evidence-led, dose-free clinical references and decision aids for teams.