Skin

Medicines for Hidradenitis suppurativa

A long-term inflammatory skin condition causing painful lumps, abscesses and scarring in skin folds such as the armpits and groin — not caused by poor hygiene, helped by stopping smoking and weight management, and treated by severity from antibiotics to biologics.

Education and reference only. This explains which medicines are used and why, in plain language — it deliberately contains no doses and is not a substitute for advice from your doctor or pharmacist. Always discuss your own treatment with a qualified clinician, and check the BNF and the product labelling for prescribing detail.

Quick answer

What is Hidradenitis suppurativa?

Hidradenitis suppurativa, often shortened to HS, is a chronic inflammatory condition of the skin that causes recurring painful lumps, abscesses and, over time, scarring. It typically affects areas where skin rubs together and where there are certain glands, such as the armpits, the groin, the buttocks and under the breasts.

  • How it is treated: Care is matched to how severe the condition is and aims to reduce flare-ups, ease pain, limit scarring and improve quality of life.
  • Self-care: Stopping smoking and working towards a healthier weight are two of the most helpful things a person can do, as both are linked to how active the condition is.
  • When to seek help: See your GP if you have recurring painful lumps, boils or abscesses in areas such as the armpits, groin, buttocks or under the breasts, especially if they keep coming back in the same places, discharge fluid or are leaving scars — early diagnosis and treatment can reduce long-term scarring, so it is worth being seen rather than waiting.

What it is

Hidradenitis suppurativa, often shortened to HS, is a chronic inflammatory condition of the skin that causes recurring painful lumps, abscesses and, over time, scarring. It typically affects areas where skin rubs together and where there are certain glands, such as the armpits, the groin, the buttocks and under the breasts. Flare-ups can be very painful, may discharge fluid, and tend to come and go, with new lumps appearing while older ones heal and scar. Although it can look like a simple infection, HS is an inflammatory condition rather than a problem of cleanliness or hygiene, and it is not contagious. It often starts after puberty and is more common in people who smoke and in those carrying excess weight, both of which can make it worse. Because the condition is painful, persistent and affects sensitive areas, it can have a significant impact on daily life and wellbeing, and early recognition helps reduce the scarring that can build up over years.

How it is treated

Care is matched to how severe the condition is and aims to reduce flare-ups, ease pain, limit scarring and improve quality of life. For milder disease, treatment may include topical antibiotics and a course of oral antibiotics from the tetracycline group, used as much for their anti-inflammatory effect as for tackling infection. As the condition becomes more active or widespread, anti-inflammatory approaches and, for moderate-to-severe HS, biologic medicines that target tumour necrosis factor (anti-TNF, such as adalimumab) may be used under specialist care to calm the underlying inflammation. Where scarring and persistent tunnels under the skin have become established, surgery to remove the affected areas can be considered. Alongside medical and surgical treatment, stopping smoking and managing weight genuinely help, and good pain control and dressings matter. Because early treatment reduces long-term scarring, referral to a dermatology specialist sooner rather than later is encouraged.

Symptom checker

Symptoms that can point to Hidradenitis suppurativa

Hidradenitis suppurativa can be one cause of these symptoms. Each guide explains the other possible causes and the red-flag warning signs that mean you should get urgent help:

Beyond medication

Lifestyle and self-care

Stopping smoking and working towards a healthier weight are two of the most helpful things a person can do, as both are linked to how active the condition is. Wearing loose, breathable clothing to reduce friction in affected areas, using gentle washing rather than harsh scrubbing, and looking after the skin during flares all help. Good wound care and dressings make discharging areas more comfortable, and because HS can be painful and wearing, support for mood and wellbeing is an important part of living with the condition.

When to get help

When to see a doctor

See your GP if you have recurring painful lumps, boils or abscesses in areas such as the armpits, groin, buttocks or under the breasts, especially if they keep coming back in the same places, discharge fluid or are leaving scars — early diagnosis and treatment can reduce long-term scarring, so it is worth being seen rather than waiting. Ask to be reviewed if existing treatment is not controlling flares, if the pain is hard to manage, or if the condition is affecting your work, relationships or mood, as referral to a skin specialist and stronger treatments are available. Seek more urgent advice if an area becomes rapidly more swollen, red, hot and painful, if you develop a fever or feel generally unwell, or if a lump suddenly enlarges, as this may need prompt treatment.

999Emergency — call 999 or go to A&E
111Urgent advice — call NHS 111 or use 111 online
GPNon-urgent — see your GP or pharmacist

Not sure how urgent it is? It is always OK to call NHS 111 for advice, day or night.

Answers

Hidradenitis suppurativa: frequently asked questions

What medicines are used for hidradenitis suppurativa?

Treatment is matched to severity. For milder disease, topical antibiotics applied to the skin and a course of oral antibiotics from the tetracycline group are commonly used, as much for their anti-inflammatory effect as for tackling infection. As the condition becomes more active, anti-inflammatory approaches and, for moderate-to-severe HS, biologic medicines that block tumour necrosis factor (anti-TNF, such as adalimumab) may be started under specialist care to calm the underlying inflammation. Surgery can be considered where scarring and tunnels under the skin are established. Stopping smoking, managing weight, good pain relief and dressings all support these treatments and are an important part of care.

Is hidradenitis suppurativa caused by poor hygiene?

No — this is a common and understandable misunderstanding, but HS is not caused by being unclean. It is a long-term inflammatory condition of the skin, not a simple infection, and washing more or harder does not prevent or cure it, and scrubbing affected areas can actually make things worse. It is also not contagious. Things that do influence it include smoking and carrying excess weight, both of which can make it more active, which is why stopping smoking and weight management are genuinely helpful. Understanding that HS is an inflammatory condition rather than a hygiene problem can lift unfair self-blame and help focus on effective treatment.

Does stopping smoking and losing weight help?

Yes — both are among the most useful steps a person with HS can take. Smoking and excess weight are linked with more active disease, so stopping smoking and working towards a healthier weight can reduce how often and how badly the condition flares, and they support the benefit of medical treatment. These changes are not always easy, and they are not a substitute for the antibiotics, biologics or surgery that may be needed, but they make a real difference over time. Your GP or specialist team can offer practical help with stopping smoking and weight management as part of your overall care plan.

When should hidradenitis suppurativa be referred to a specialist?

Referral to a dermatology specialist is encouraged sooner rather than later, because early treatment helps reduce the long-term scarring that can build up. It is particularly worth being referred if flares are frequent or hard to control, if simpler treatments such as antibiotics are not keeping the condition in check, if scarring or tunnels under the skin are developing, or if the pain and impact on daily life are significant. A specialist can offer treatments such as anti-TNF biologics and assess whether surgery to remove badly affected areas would help. Asking your GP about referral early gives the best chance of limiting lasting damage.

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