Urology
Medicines for Kidney infection
A urinary infection that has reached the kidney — causing fever, chills and back or side pain, and needing prompt antibiotics, with hospital treatment for those who are very unwell, pregnant or not improving.
Education and reference only. This explains which medicines are used and why, in plain language — it deliberately contains no doses and is not a substitute for advice from your doctor or pharmacist. Always discuss your own treatment with a qualified clinician, and check the BNF and the product labelling for prescribing detail.
Quick answer
What is Kidney infection?
A kidney infection, known medically as pyelonephritis, is a urinary tract infection that has travelled up from the bladder to reach one or both kidneys. It is more serious than a simple bladder infection (cystitis) and tends to make people feel quite unwell.
- How it is treated: A kidney infection is treated promptly with antibiotics, and the priority is to start treatment quickly rather than waiting.
- Self-care: While antibiotics do the main work of clearing a kidney infection, there are things that help you recover and lower the chance of another one.
- When to seek help: Contact your GP or an urgent care service promptly if you think you have a kidney infection — particularly a high temperature, shivering, and pain in your back or side, with or without the burning and frequency of a bladder infection — as it needs assessment and antibiotics without delay.
What it is
A kidney infection, known medically as pyelonephritis, is a urinary tract infection that has travelled up from the bladder to reach one or both kidneys. It is more serious than a simple bladder infection (cystitis) and tends to make people feel quite unwell. Typical features include a high temperature, shivering or chills, pain in the back or side (the flank), feeling sick or being sick, and often the symptoms of a bladder infection too — needing to pass urine often and urgently, pain or burning when passing urine, and cloudy or smelly urine. It is usually caused by bacteria that normally live in the bowel finding their way into the urinary tract. Women are affected more often than men because of their shorter urethra, and the risk is higher in pregnancy, with a urinary catheter, with kidney stones or anything that blocks the flow of urine, and in those with diabetes or a weakened immune system. Because a kidney infection can occasionally lead to serious complications, it needs prompt assessment and treatment, with a urine sample usually sent to the laboratory to identify the bacteria responsible.
How it is treated
A kidney infection is treated promptly with antibiotics, and the priority is to start treatment quickly rather than waiting. Because the infection involves the kidney rather than just the bladder, the antibiotic course is usually longer and may be a different choice from that used for simple cystitis. A urine sample is normally sent to the laboratory so the bacteria can be identified and their sensitivity tested; the initial antibiotic is chosen on the best available guidance and then adjusted if the laboratory result suggests a better match. Drinking enough fluids and using simple pain relief to ease fever and discomfort support recovery. Most people can be treated at home with tablets and start to feel better within a couple of days. Some, however, need hospital care — for example if they are very unwell, cannot keep fluids or tablets down because of vomiting, are pregnant, have signs of a more serious infection, or are not improving despite treatment; in hospital, antibiotics and fluids can be given directly into a vein. If an underlying problem such as a stone or blockage is found, this is investigated and managed too, as it can keep an infection going.
For this condition, these medicines
Medicine classes used for Kidney infection
Each links to a full, dose-free guide — what it is, how it works, who can and cannot use it, side effects, interactions and FAQs.
Symptom checker
Symptoms that can point to Kidney infection
Kidney infection can be one cause of these symptoms. Each guide explains the other possible causes and the red-flag warning signs that mean you should get urgent help:
Beyond medication
Lifestyle and self-care
While antibiotics do the main work of clearing a kidney infection, there are things that help you recover and lower the chance of another one. During the illness, rest and drink enough fluids to keep your urine pale, unless your doctor has advised you to limit fluids; simple pain relief can ease the fever and the back or side pain. Finish the full course of antibiotics exactly as prescribed, even once you feel better, and go back to your doctor if you are not improving after a couple of days. To reduce the risk of future urinary infections, drink plenty of water through the day, do not hold on when you need to pass urine, empty your bladder fully, and wipe from front to back. Passing urine after sex, treating constipation, and managing any long-term conditions such as diabetes all help. If you keep getting infections, your doctor may look for an underlying cause such as a stone or a problem with urine flow.
When to get help
When to see a doctor
Contact your GP or an urgent care service promptly if you think you have a kidney infection — particularly a high temperature, shivering, and pain in your back or side, with or without the burning and frequency of a bladder infection — as it needs assessment and antibiotics without delay. Seek help the same day if you are pregnant and have any urinary symptoms, if you cannot keep fluids or tablets down, if you are not improving within about 24 to 48 hours of starting antibiotics, or if you have a long-term condition such as diabetes or a weakened immune system. Call 999 or go to A&E if you develop signs of a serious, spreading infection (sepsis): a very high or very low temperature with violent shivering (rigors), a fast heartbeat or breathing, severe pain, confusion or drowsiness, little or no urine, or feeling that something is seriously wrong. These are emergencies.
Not sure how urgent it is? It is always OK to call NHS 111 for advice, day or night.
Answers
Kidney infection: frequently asked questions
What medicines are used for a kidney infection?
The essential treatment is antibiotics, and starting them promptly matters. Because the infection involves the kidney rather than just the bladder, the course is usually longer and may be a different antibiotic from the one used for a simple bladder infection. A urine sample is normally sent to the laboratory so the exact bacteria can be identified and the antibiotic adjusted to match if needed. Cephalosporins are one group commonly used, including as an option in pregnancy and as an injection into a vein in hospital for those who are more unwell. Simple pain relief and good fluid intake support recovery. Most people improve within a day or two; those who are very unwell, pregnant or vomiting may need hospital treatment.
When does a kidney infection need hospital treatment?
Many kidney infections can be treated at home with antibiotic tablets, but some need hospital care. This is more likely if you are very unwell, cannot keep fluids or tablets down because of vomiting, are pregnant, have signs of a more serious or spreading infection, or are not getting better despite treatment. People with diabetes, a weakened immune system, a urinary catheter, or a known kidney stone or blockage may also need closer assessment. In hospital, antibiotics and fluids can be given directly into a vein, which works faster and is more reliable when someone cannot take or absorb tablets. Any underlying problem, such as a stone obstructing urine flow, can also be investigated and treated there.
How is a kidney infection different from a bladder infection (cystitis)?
Both are urinary tract infections, but they affect different parts of the system and differ in severity. Cystitis is an infection of the bladder and tends to cause local symptoms: needing to pass urine often and urgently, burning or stinging when you go, and cloudy or smelly urine, usually without making you feel generally unwell. A kidney infection happens when the infection travels further up to involve the kidney itself, and it tends to make you feel much more poorly — with a high temperature, shivering or chills, pain in the back or side, and often feeling sick. Because of this, a kidney infection needs prompt antibiotics and, usually, a urine sample sent to the laboratory.
Can a kidney infection cause lasting harm?
Treated promptly, most kidney infections clear up fully without lasting damage. The reason to take them seriously is that, if left untreated or if the person is particularly vulnerable, the infection can occasionally spread into the bloodstream and cause sepsis, a life-threatening illness, or lead to other complications. Repeated kidney infections, or one linked to an underlying problem such as a stone or blockage, can over time contribute to kidney scarring, which is why doctors sometimes look for an underlying cause. The key messages are to seek help early, complete the antibiotic course, and get urgent care if you develop warning signs such as confusion, violent shivering, severe pain or producing little urine.
Keep reading
Related articles
Sources
Where this is drawn from
- NICE CKS: Pyelonephritis - acute.
- British Association of Urological Surgeons
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