Neurology

Corrected Phenytoin (Sheiner-Tozer)

Albumin-adjusted phenytoin level.

Education and reference only. Not a substitute for clinical judgement, local policy or product labelling. Always verify before clinical use. Values are calculated in your browser and never stored.

When to use

Use to estimate the true phenytoin level in hypoalbuminaemia, since phenytoin is highly protein-bound.

Why use

A normal total level can be misleading when albumin is low; correction reveals the effective level.

Critical actions

Albumin in g/dL (divide g/L by 10). For significant renal impairment use the Sheiner-Tozer renal variant. Always interpret with clinical state, not the number alone.

Evidence & references

  1. Sheiner LB, Tozer TN. Clinical Pharmacokinetics: the use of plasma concentrations of drugs. 1978.

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